Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov-Dec;4(6 Suppl):158S-166S.
doi: 10.1016/j.spinee.2004.07.010.

Molecular basis of intervertebral disc degeneration

Matthew H Walker  1 , D Greg Anderson
Affiliations
Review

Molecular basis of intervertebral disc degeneration

Matthew H Walker et al. Spine J. 2004 Nov-Dec.

Abstract

This review will acquaint the reader with normal development, structure, and function of the intervertebral disc. The disc is composed of the vertebral endplate, nucleus pulposus, and annulus fibrosus. These three functional components all serve important purposes for health and function of the disc. Nutrition and biomechanics are also discussed. The molecular basis of disc degeneration is reviewed so that biologic approaches to the reversal and or treatment of disc degeneration may be better understood.

PubMed Disclaimer

MeSH terms

LinkOut - more resources