Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Nov;6(5):447-58.
doi: 10.1016/j.ccr.2004.09.028.

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

Affiliations
Free article

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

Anke Sparmann et al. Cancer Cell. 2004 Nov.
Free article

Abstract

The role of Ras oncogenes in promoting cellular transformation is well established. However, the contribution of Ras signaling to interactions between tumor cells and their host environment remains poorly characterized. Here, we demonstrate that the inflammatory mediator interleukin-8 (CXCL-8/IL-8) is a transcriptional target of Ras signaling. Using a tumor xenograft model, we show that Ras-dependent CXCL-8 secretion is required for the initiation of tumor-associated inflammation and neovascularization. Collectively, our data identify a novel mechanism by which the Ras oncogene can elicit a stromal response that fosters cancer progression.

PubMed Disclaimer

Publication types

MeSH terms

Substances