doi: 10.1590/s0074-02762004000500005.
Epub 2004 Nov 3.
Production of L-asparaginase by filamentous fungi
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- PMID: 15543411
- DOI: 10.1590/s0074-02762004000500005
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Production of L-asparaginase by filamentous fungi
Mem Inst Oswaldo Cruz.
2004 Aug.
Free article
Abstract
L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2% proline medium. Both fungi presented the lowest level of L-asparaginase production in the presence of glutamine and urea as nitrogen sources. These results suggest that L-asparaginase production by of filamentous fungi is under nitrogen regulation.
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