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. 1992;5(2):102-6.
doi: 10.1002/mc.2940050204.

Formation of stable p53 homotetramers and multiples of tetramers

J E Stenger  1 , G A Mayr, K Mann, P Tegtmeyer
Affiliations

Formation of stable p53 homotetramers and multiples of tetramers

J E Stenger et al. Mol Carcinog. 1992.

Abstract

We have used gradient gel electrophoresis and chemical cross-linking to analyze the quaternary structure of purified, wild-type, murine p53. Under nondenaturing conditions, p53 electrophoreses as tetramers and multiples of tetramers. Under denaturing conditions, fully cross-linked p53 also behaves as tetrameric structures. We confirmed the composition of the tetramers by partially cross-linking p53 and dissociating tetramers into monomers, dimers, and trimers.

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