Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Nov-Dec;12(6):648-52.
doi: 10.1176/appi.ajgp.12.6.648.

Neural basis for the cognitive continuum in episodic memory from health to Alzheimer disease

Georg Grön  1 , Matthias W Riepe
Affiliations

Neural basis for the cognitive continuum in episodic memory from health to Alzheimer disease

Georg Grön et al. Am J Geriatr Psychiatry. 2004 Nov-Dec.

Abstract

Objective: The authors hypothesize that, behaviorally, episodic memory in health and disease reflects a continuum.

Methods: Subjects (N=12) with very mild Alzheimer disease (AD) and normal subjects (N=24) were investigated with functional magnetic resonance imaging (fMRI) during an episodic memory task.

Results: Recruitment of a posterior medio-temporal network was correlated with memory performance across the spectrum from high- and low-performing normal subjects to patients with early AD.

Conclusions: The behavioral spectrum from health to disease in episodic memory function is mirrored neurobiologically with graded recruitment of neuronal activation in medio-temporal regions. The results call for longitudinal assessment of behavioral decline and neuronal recruitment in future studies.

PubMed Disclaimer

MeSH terms