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Comparative Study
. 2004 Nov-Dec;6(6):487-94.
doi: 10.1097/01.gim.0000144017.39690.4e.

Maternal meiosis II nondisjunction in trisomy 21 is associated with maternal low socioeconomic status

Roberta E Christianson  1 , Stephanie L Sherman, Claudine P Torfs
Affiliations
Free article
Comparative Study

Maternal meiosis II nondisjunction in trisomy 21 is associated with maternal low socioeconomic status

Roberta E Christianson et al. Genet Med. 2004 Nov-Dec.
Free article

Abstract

Purpose: We evaluated whether the association of socioeconomic risk factors for trisomy 21 differed by type of maternal meiotic error.

Methods: We determined meiotic errors by DNA analysis for 150 trisomy 21 cases, and maternal lifetime exposures to low socioeconomic factors by questionnaire.

Results: Mothers of meiosis II cases were significantly more likely to be exposed to four low socioeconomic factors than mothers of meiosis I cases (odds ratio = 9.50; 95% confidence interval = 1.8-49.8).

Conclusion: Maternal lifetime exposure to poor socioeconomic environment is a risk factor for a trisomy 21, particularly if nondisjunction leads to a maternal meiosis II.

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