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Review
. 2004 Dec:202:203-22.
doi: 10.1111/j.0105-2896.2004.00209.x.

Signaling pathways in Th2 development

Kerri A Mowen  1 , Laurie H Glimcher
Affiliations
Review

Signaling pathways in Th2 development

Kerri A Mowen et al. Immunol Rev. 2004 Dec.

Abstract

In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.

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