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Review
. 2004 Dec:202:223-36.
doi: 10.1111/j.0105-2896.2004.00216.x.

Interleukin-10 in viral diseases and cancer: exiting the labyrinth?

Alain P Vicari  1 , Giorgio Trinchieri
Affiliations
Review

Interleukin-10 in viral diseases and cancer: exiting the labyrinth?

Alain P Vicari et al. Immunol Rev. 2004 Dec.

Abstract

Interleukin-10 (IL-10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL-10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.

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