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. 2004 Oct 29;9(10):479-84.

IgM-enriched immunoglobulin (pentaglobin) positively influences the course of post-surgical intra-abdominal infections

H B Reith  1 , S K Rauchschwalbe, U Mittelkötter, R Engemann, A Thiede, A Arnold, R Lissner
Affiliations
  • PMID: 15546815

IgM-enriched immunoglobulin (pentaglobin) positively influences the course of post-surgical intra-abdominal infections

H B Reith et al. Eur J Med Res. .

Abstract

Background: Polyvalent IgM-enriched intravenous human immunoglobulin (IVIG) preparations are discussed to be beneficial regarding sepsis outcome.

Materials and methods: Sixty-four patients with abdominal infection were treated with Pentaglobin or Albumin. Serum levels of endotoxin and chemokines were determined.

Results: Incidence of fever was 19/28 in the pentaglobin and 18/26 in the albumin group, the percentage of days with fever was 34 +/- 26 for pentaglobin and 43 +/- 25 for albumin (mean +/-SD). Procalcitonin levels of the pentaglobin treated patients fell under the upper limit of normal on day six whereas levels of albumin patients remained elevated.

Conclusion: Pentaglobin has a positive influence on the course of post-surgery intra-abdominal infection.

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