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. 2004 Dec;90(12):1398-403.
doi: 10.1136/hrt.2003.026104.

Cardiovascular disease incidence and mortality in older men with diabetes and in men with coronary heart disease

S G Wannamethee  1 , A G Shaper, L Lennon
Affiliations

Cardiovascular disease incidence and mortality in older men with diabetes and in men with coronary heart disease

S G Wannamethee et al. Heart. 2004 Dec.

Abstract

Objective: To examine the relation of diabetes and coronary heart disease (CHD; myocardial infarction (MI) or angina) to the incidence of major CHD and stroke events and total mortality.

Methods: Prospective study of 5934 men aged 52-74 years followed up for 10 years. The men were divided into five groups according to their diabetes and CHD status.

Results: During the follow up there were 662 major CHD events, 305 major stroke events, and 1357 deaths from all causes (637 cardiovascular disease (CVD) deaths, 417 CHD deaths). Men with diabetes had significantly increased cardiovascular and total mortality risk compared with non-diabetic men with no CHD but lower risk than men with prior MI only. The adjusted relative risk for CHD deaths was 2.82 (95% confidence interval (CI) 1.85 to 4.28) in men with diabetes only, 2.12 (95% CI 1.53 to 2.93) in men with angina only, 3.91 (95% CI 3.07 to 4.99) in men with MI, and 8.93 (95% CI 6.13 to 12.99) in men with both diabetes and CHD. Case fatality among men with diabetes only was similar to those with prior MI only. CHD and CVD mortality increased with increasing duration of diabetes with risk eventually approaching that of patients with MI without diabetes.

Conclusion: Men with diabetes only have a CVD risk intermediate between men with angina and men with prior MI. Their absolute risk is high and the prognosis for diabetic patients who develop CHD is extremely poor.

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Figures

Figure 1
Figure 1
Kaplan-Meier estimates of probability of survival (%) for (A) coronary heart disease (CHD), (B) cardiovascular disease (CVD), and (C) all cause mortality stratified by history of diabetes (DM) and CHD. Survival probabilities were virtually identical for the angina group and the DM only group. MI, myocardial infarction.
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References

    1. Haffner SM, Lehto S, Ronnema T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998;339:229–34. - PubMed
    1. Mittinen H, Lehto S, Salomma VV, et al. Impact of diabetes on mortality after the first myocardial infarction. Diabetes Care 1998;21:69–75. - PubMed
    1. Mukamal KJ, Maclure M, Nesto RW, et al. Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction. Diabetes Care 2001;24:1422–7. - PubMed
    1. Malmberg K, Yusuf S, Gerstein H, et al. Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: result of the OASIS (organization to assess strategies for ischemic syndromes) registry. Circulation 2000;102:1014–9. - PubMed
    1. Anon. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;385:2486–97. - PubMed

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