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. 2004 Nov;191(5):1649-54.
doi: 10.1016/j.ajog.2004.04.014.

Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants

Hiromi An  1 , Shigeru Nishimaki, Makiko Ohyama, Atsushi Haruki, Takuya Naruto, Naoki Kobayashi, Toshiyuki Sugai, Yoshinori Kobayashi, Masaaki Mori, Kazuo Seki, Shumpei Yokota
Affiliations

Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants

Hiromi An et al. Am J Obstet Gynecol. 2004 Nov.

Abstract

Objectives: In order to predict the late-development of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study.

Study design: Eighteen premature infants with CLD were enrolled. Cord blood plasma levels of cytokines of these infants and 12 control infants without CLD were measured including interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, soluble TNF receptor-I, and soluble IL-6 receptor using a cytometric bead array and an enzyme-linked immunosorbent assay.

Results: The cord blood IL-6, IL-8, and sTNFR-I levels were significantly elevated in CLD infants compared with those in control (P < .05). IL-1beta, IL-2, IL-4, IL-10, and IFN-gamma were undetectable in both groups. CLD infants with maternal chorioamnionitis had higher IL-6 than those without chorioamnionitis (P < .01). In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy (P < .05).

Conclusion: Elevated inflammatory cytokines in the cord blood are associated with the progression to CLD.

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