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. 2004 Nov 25;6(24):4543-6.
doi: 10.1021/ol048111g.

Ruthenium-catalyzed [2 + 2] cycloadditions between bicyclic alkenes and alkynyl halides

Karine Villeneuve  1 , Nicole Riddell, Robert W Jordan, Gavin C Tsui, William Tam
Affiliations

Ruthenium-catalyzed [2 + 2] cycloadditions between bicyclic alkenes and alkynyl halides

Karine Villeneuve et al. Org Lett. .

Abstract

Ru-catalyzed [2 + 2] cycloadditions between norbornadiene and alkynyl halides were found to occur in moderate to good yields (32-89%). The presence of the halide moiety greatly enhances the reactivity of the alkyne component in the cycloaddition and can be transformed into a variety of products that are difficult or impossible to obtain via direct cycloaddition. [reaction: see text]

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