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Case Reports
. 1992 Feb;26(2):211-2.
doi: 10.1177/106002809202600215.

Fluoxetine-induced psoriasis

C Hemlock  1 , J S Rosenthal, A Winston
Affiliations
Case Reports

Fluoxetine-induced psoriasis

C Hemlock et al. Ann Pharmacother. 1992 Feb.

Abstract

Background: A number of medications have been reported to induce psoriasis. We report two cases of fluoxetine-related psoriasis and discuss similarities between lithium-, trazodone hydrochloride-, and fluoxetine-induced psoriasis.

Observations: Two women being treated for depression with fluoxetine developed psoriasis after 6 and 12 months' exposure. This time frame is clinically similar to that observed with lithium-induced psoriasis.

Conclusions: The occurrence of lithium- and fluoxetine-induced psoriasis may not be random. Both drugs modulate serotonergic function, a factor that may contribute to the pathophysiology of psoriasis. If a patient on acute or long-term fluoxetine therapy develops psoriasis, the drug should be considered as a possible etiologic agent.

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