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Review
. 2005 Mar;20(3):380-2.
doi: 10.1007/s00467-004-1623-9. Epub 2004 Nov 10.

Impact of inflammation and oxidative stress on vascular calcifications in chronic kidney disease

Z A Massy  1 , C Mazière, S Kamel, M Brazier, G Choukroun, C Tribouilloy, M Slama, M Andrejak, J C Mazière
Affiliations
Review

Impact of inflammation and oxidative stress on vascular calcifications in chronic kidney disease

Z A Massy et al. Pediatr Nephrol. 2005 Mar.

Abstract

Vascular and/or valvular calcifications in patients with chronic kidney disease (CKD) appear to indicate a poor prognosis in terms of overall survival and cardiovascular morbidity and mortality. Inflammation and oxidative stress represent new features of the arterial and/or valvular calcification process. However, only limited observational and epidemiological data are available in these areas. Therefore, the link between inflammation, oxidation and vascular and/or valvular calcifications deserves careful consideration in CKD patients, since they may become targets for the development of new therapeutic strategies.

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