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Case Reports
. 2004 Dec;77(4):391-6.
doi: 10.1002/ajh.20202.

Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Sa Wang  1 , Barbara A Degar, Arthur Zieske, Nelofar Q Shafi, Michal G Rose
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Free article
Case Reports

Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Sa Wang et al. Am J Hematol. 2004 Dec.
Free article

Abstract

We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.

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