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Review
. 2004 Dec;8(6):645-53.
doi: 10.1016/j.cbpa.2004.09.003.

Nucleic-acid-templated synthesis as a model system for ancient translation

Christopher T Calderone  1 , David R Liu
Affiliations
Review

Nucleic-acid-templated synthesis as a model system for ancient translation

Christopher T Calderone et al. Curr Opin Chem Biol. 2004 Dec.

Abstract

The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesis in the context of requirements for prebiotic translation. This analysis highlights the chemical possibilities of ancient translation systems, as well as challenges that these systems may have faced.

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