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. 2004 Dec;11(12):1251-2.
doi: 10.1038/nsmb866. Epub 2004 Nov 21.

Structure of a purine-purine wobble base pair in the decoding center of the ribosome

Frank V Murphy 4th  1 , V Ramakrishnan
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Structure of a purine-purine wobble base pair in the decoding center of the ribosome

Frank V Murphy 4th et al. Nat Struct Mol Biol. 2004 Dec.

Abstract

Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.

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