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. 2004 Dec;57(12):1299-301.
doi: 10.1136/jcp.2004.017566.

The role of serum insulin-like growth factor I (IGF-I) in neonatal outcome

A R Hayati  1 , F C Cheah, J F Yong, A E Tan, W M Norizah
Affiliations

The role of serum insulin-like growth factor I (IGF-I) in neonatal outcome

A R Hayati et al. J Clin Pathol. 2004 Dec.

Abstract

Aims: To determine the role of serum insulin-like growth factor I (IGF-I) in predicting the occurrence of septal hypertrophic cardiomyopathy in infants of mothers with diabetes.

Methods/materials: In this prospective study, 100 pregnant women (50 with diabetes and 50 controls), matched for age and race, were studied. One intrapartum blood sample was taken at 28 weeks of gestation from both groups of mothers and another sample at delivery. All samples were analysed for maternal IGF-I by an enzyme linked immunosorbent assay method. A chest radiograph and an electrocardiogram were performed on the babies of the mothers with diabetes within the first 24 hours of life. An echocardiogram was performed in the first 3 days of life to look for septal hypertrophy and to measure the myocardial thickness.

Results: In the six cases of neonatal septal hypertrophic cardiomyopathy, all the mothers had greatly raised IGF-I concentrations of more than 400 ng/ml at the time of delivery compared with a mean (SD) of 302 (25) ng/ml in control mothers.

Conclusions: In the present study a crude analysis revealed that increased IGF-I concentrations correlate with neonatal septal hypertrophic cardiomyopathy.

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Figures

Figure 1
Figure 1
Mean serum insulin-like growth factor (IGF-I) concentrations in mothers with diabetes and control mothers during two periods of gestation (28 weeks and 36 weeks).
Figure 2
Figure 2
Mean serum insulin-like growth factor (IGF-I) concentrations in mothers with diabetes whose babies had neonatal septal hypertrophic cardiomyopathy and control mothers at the time of delivery.
See this image and copyright information in PMC

References

    1. Boo NY. Morbidity and mortality of infants of diabetic mothers at Maternity Hospital Kuala Lumpur. Med J Malaysia 1992;41:56–9. - PubMed
    1. Yan-Jun L, Tsushima T, Mind S, et al. Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBP-l, 2, and 3) in diabetic pregnancy: relationship to macrosomia. Endocr J 1996;43:221–31. - PubMed
    1. Linda BJ, Jovanna D, Juliane N, et al. Association between insulin like growth factor I (IGF-I) polymorphism, circulating IGF-I, and pre and postnatal growth in two European small for gestation age populations. J Clin Endocrinol Metab 2003;88:4805–10. - PubMed
    1. Baker J, Liu JP, Robertson EJ, et al. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993;75:73–82. - PubMed
    1. Liu JP, Baker J, Perkins AS, et al. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I) and type 1 IGF receptor (IGFIR). Cell 1993;75:59–72. - PubMed

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