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Review
. 2004 Dec;25(4):727-38, vi-vii.
doi: 10.1016/j.ccm.2004.06.003.

Cryptogenic organizing pneumonia

Jean-François Cordier  1
Affiliations
Review

Cryptogenic organizing pneumonia

Jean-François Cordier. Clin Chest Med. 2004 Dec.

Abstract

Cryptogenic organizing pneumonia is a rare, distinct disorder that is sufficiently different from the other diseases in the group of idiopathic interstitial pneumonias to be designated as a separate entity. In its most typical presentation, it is characterized by dyspnea and cough, with multiple patchy alveolar opacities on pulmonary imaging. Definite diagnosis is obtained by the finding of buds of granulation tissue in the distal airspaces at lung biopsy. No cause (as infection, drug reaction, or associated disease as connective tissue disease) is found. Corticosteroid treatment is rapidly effective, but relapses are common on reducing or stopping treatment.

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Figures

Fig. 1
Fig. 1
Buds of granulation tissue in the lumen of the distal airspaces.
Fig. 2
Fig. 2
Chest radiograph in a patient with typical COP. (A) Patchy alveolar opacity of right lower lobe. (B) Six days later, the distribution of the right lower lobe opacity changed, and a new contralateral basal opacity appeared.
Fig. 2
Fig. 2
Chest radiograph in a patient with typical COP. (A) Patchy alveolar opacity of right lower lobe. (B) Six days later, the distribution of the right lower lobe opacity changed, and a new contralateral basal opacity appeared.
Fig. 3
Fig. 3
HRCT in typical COP. (A) Patchy bilateral opacities in the lower lobes. (B) Bilateral extensive consolidation with air bronchogram in the lower lobes.
Fig. 3
Fig. 3
HRCT in typical COP. (A) Patchy bilateral opacities in the lower lobes. (B) Bilateral extensive consolidation with air bronchogram in the lower lobes.
Fig. 4
Fig. 4
HRCT in solitary focal COP shows a pseudo-neoplastic mass.
See this image and copyright information in PMC

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MeSH terms