Review
doi: 10.1159/000082104.
Treatment of SLE with anti-CD20 monoclonal antibody
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- PMID: 15564722
- DOI: 10.1159/000082104
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Review
Treatment of SLE with anti-CD20 monoclonal antibody
Curr Dir Autoimmun.
2005.
Abstract
Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organ systems and characterized by anti-nuclear antibodies. While T cells and dendritic cells may play major roles in SLE, several lines of evidence strongly suggest a central role for B cells. This article will review the role of B cells in human SLE as well as the currently available data on the treatment of SLE by depleting B cells with anti-CD20 (rituximab).
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