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. 2005 Jan 7;326(1):242-8.
doi: 10.1016/j.bbrc.2004.11.016.

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki  1 , Megumi Kurita, Kiyohisa Mizumoto, Masatsugu Moriyama, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka
Affiliations

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki et al. Biochem Biophys Res Commun. .

Abstract

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

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