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Review
. 2004 Dec;10(12):585-90.
doi: 10.1016/j.molmed.2004.10.003.

Salivary glands: novel target sites for gene therapeutics

Bruce J Baum  1 , Antonis Voutetakis, Jianghua Wang
Affiliations
Review

Salivary glands: novel target sites for gene therapeutics

Bruce J Baum et al. Trends Mol Med. 2004 Dec.

Abstract

Directing the local or systemic expression of therapeutic proteins is a potentially important clinical application of gene transfer technology. Gene-based therapeutics theoretically offer many advantages over protein therapeutics. Numerous tissues have been evaluated for this purpose in animal models, most commonly the liver and skeletal muscle. Based on pre-clinical studies, we suggest that salivary glands are a valuable, yet under-appreciated, target tissue for both systemic and upper gastrointestinal tract gene therapeutic applications.

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