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Comparative Study
. 2004 Jul;20(4):271-3.

[Expression and significance of alpha5beta1 integrin in abnormal scars]

[Article in Chinese]
You Yu  1 , Guang-Zhao He, Yi Wu, Chong-Ben Huang
Affiliations
  • PMID: 15568751
Comparative Study

[Expression and significance of alpha5beta1 integrin in abnormal scars]

[Article in Chinese]
You Yu et al. Zhonghua Zheng Xing Wai Ke Za Zhi. 2004 Jul.

Abstract

Objective: To study the expression of alpha5beta1 integrin in the abnormal scars and its role and significance in the formation and development of abnormal scars.

Methods: The expression of alpha5beta1 integrin was observed in hypertrophic scar (15 samples), keloid (15 samples) and normal skin (10 samples) with SP immunohistochemical method and colloidal gold immuno-electron microscopic technique. The data were semi-quantitatively analyzed.

Results: The expression levels of alpha5beta1 integrin in the fibroblasts of keloids and hypertrophic scars were higher than normal skin; the expression of alpha5beta1 integrin in the fibroblasts of keloids was higher than hypertrophic scars (P < 0.01).

Conclusion: The alpha5beta1 integrin appears to have close relation to the formation and development of abnormal scars. To find a way to decrease the expression level of alpha5beta1 integrin in fibroblasts may be a new approach to inhibit scar hypertrophy.

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