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. 2004 Nov;67(11):1800-3.
doi: 10.1021/np0401462.

Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica

Chihiro Ito  1 , Masataka Itoigawa, Akiko Furukawa, Takashi Hirano, Tomiyasu Murata, Norio Kaneda, Youichi Hisada, Kazuyo Okuda, Hiroshi Furukawa
Affiliations

Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica

Chihiro Ito et al. J Nat Prod. 2004 Nov.

Abstract

Four new quinolone alkaloids, orixalone A (1), B (2), C (3), and D (4), together with 12 known compounds were isolated from the stems of Orixa japonica. Orixalone A (1) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma and lipopolysaccharide.

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