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Review
. 2004:38:203-32.
doi: 10.1146/annurev.genet.38.072902.093051.

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation

Frank Stegmeier  1 , Angelika Amon
Affiliations
Review

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation

Frank Stegmeier et al. Annu Rev Genet. 2004.

Abstract

Completion of the cell cycle requires the temporal and spatial coordination of chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding yeast, the protein phosphatase Cdc14 is a key regulator of these late mitotic events. Here, we review the functions of Cdc14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc14 in other eukaryotes, emphasizing conserved features.

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Comment in

  • Cdc14b: a new player in aging.
    Wei Z, Zhang P. Wei Z, et al. Aging (Albany NY). 2011 May;3(5):456. doi: 10.18632/aging.100332. Aging (Albany NY). 2011. PMID: 21666283 Free PMC article. No abstract available.

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