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. 2004 Nov-Dec;25(10):1709-14.

Evaluation of cortical atrophy between progressive supranuclear palsy and corticobasal degeneration by hemispheric surface display of MR images

Masato Taki  1 , Kazunari Ishii, Tetsuya Fukuda, Yoshio Kojima, Etsuro Mori
Affiliations

Evaluation of cortical atrophy between progressive supranuclear palsy and corticobasal degeneration by hemispheric surface display of MR images

Masato Taki et al. AJNR Am J Neuroradiol. 2004 Nov-Dec.

Abstract

Background and purpose: Three-dimensional imaging and hemispheric volumetry are useful for the assessment of degenerative cortical atrophy. Our purpose was to determine the features of cortical atrophy in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) by means of a hemispheric surface display generated with MR images.

Methods: The extent of cortical atrophy was evaluated with automated MR hemispheric surface display and volumetry in 19 patients with PSP and 19 with CBD.

Results: Most cortical regions were less atrophic in PSP than in CBD. The parietal lobe, paracentral regions, anterior middle frontal lobe, and posterior inferior frontal lobe were significantly more atrophic in CBD than in PSP, whereas the brainstem was significantly more atrophic in PSP. The mean hemisphere-to-intracranial volume ratio was significantly greater in patients with PSP (74.5%) than in those with CBD (71.4%), whereas the mean brainstem-to-intracranial volume ratio was significantly smaller in PSP (1.4%) than in CBD (1.6%). Asymmetry of hemispheric volume was significantly larger in the CBD group than in the PSP group.

Conclusion: Hemispheric surface display and volumetry are generally helpful and especially useful for the differentiation of PSP and CBD.

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Figures

F<sc>ig</sc> 1.
Fig 1.
3D volume-rendered images reconstructed from thin-section coronal 3D SPGR MR images (TR/TE, 14/3; field of view, 220 mm; matrix, 256 × 256; 124 × 1.5-mm contiguous sections; flip angle, 20°) show mild diffuse atrophy of cerebral cortex and moderate atrophy of brainstem in a 67-year-old woman with PSP (MMSE score of 21).
F<sc>ig</sc> 2.
Fig 2.
3D volume-rendered images reconstructed from thin-section coronal 3D SPGR MR images (TR/TE, 14/3; field of view, 220 mm; matrix, 256 × 256; 124 × 1.5-mm contiguous section; flip angle, 20°) show severe frontoparietal atrophy in a 63-year-old woman with CBD (MMSE score of 19).
F<sc>ig</sc> 3.
Fig 3.
Light gray and dark gray areas are regions where atrophy was rated significantly more severe in the CBD and PSP groups, respectively.
See this image and copyright information in PMC

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