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Case Reports
. 2004;5(6):534-7.
doi: 10.1038/sj.thj.6200561.

Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases

José L Vizmanos  1 , Roberto Hernández, María J Vidal, María J Larráyoz, María D Odero, Julián Marín, María T Ardanaz, María J Calasanz, Nicholas C P Cross
Affiliations
Case Reports

Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases

José L Vizmanos et al. Hematol J. 2004.

Abstract

We report two new cases with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion. Case 1 presented with polycythaemia vera (PV) and evolved over 4 years to a myeloproliferative disorder (MPD) resembling the 8p11 myeloproliferative syndrome (EMS). Case 2 presented with B-cell lymphoblastic leukaemia (B-ALL). These cases illustrate the clinical heterogeneity observed in patients with FGFR1 rearrangements and suggest that constitutively activated tyrosine kinases may be more widespread in MPDs.

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