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. 2004 Nov 30:3:26.
doi: 10.1186/1476-511X-3-26.

The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee

Elisabeth Strandhagen  1 , Henrik Zetterberg, Nibia Aires, Mona Palmér, Lars Rymo, Kaj Blennow, Dag S Thelle
Affiliations

The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee

Elisabeth Strandhagen et al. Lipids Health Dis. .

Abstract

Background: The response of serum cholesterol to diet may be affected by the apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 polymorphism, which also is a significant predictor of variation in the risk of coronary heart disease (CHD) and CHD death. Here, we test the hypothesis that the APOE polymorphism may modulate the cholesterol-raising effect of coffee.

Objective: We determined the effect of a coffee abstention period and a daily intake of 600 mL coffee on serum cholesterol and triglycerides with respect to the APOE polymorphism.

Design: 121 healthy, non-smoking men (22%) and women (78%) aged 29-65 years, took part in a study with four intervention periods: 1 and 3) a coffee free period of three weeks, 2 and 4) 600 mL coffee/day for four weeks.

Results: APOE epsilon2 positive individuals had significantly lower total cholesterol concentration at baseline (4.68 mmol/L and 5.28 mmol/L, respectively, p = 0.01), but the cholesterol-raising effect of coffee was not influenced significantly by APOE allele carrier status.

Conclusions: The APOE epsilon 2 allele is associated with lower serum cholesterol concentration. However, the APOE polymorphism does not seem to influence the cholesterol-raising effect of coffee.

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Figures

Figure 1
Figure 1
Study design
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