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Review
. 2004 Dec;4(12):978-87.
doi: 10.1038/nrc1504.

Netrin-1 and its receptors in tumorigenesis

Hirofumi Arakawa  1
Affiliations
Review

Netrin-1 and its receptors in tumorigenesis

Hirofumi Arakawa. Nat Rev Cancer. 2004 Dec.

Abstract

Netrin-1 and its receptors DCC (deleted in colorectal cancer) and the UNC5 orthologues (human UNC5A-D and rodent UNC5H1-4) define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis. Accumulating evidence implies that for human cancers, this positive signalling pathway is frequently inactivated. Surprisingly, binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis, and p53 is directly involved in transcriptional regulation of netrin-1 and its receptors. So, the netrin-1 receptor pathways probably play an important part in tumorigenesis.

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