Review
doi: 10.1038/nrm1530.
The DNA-polymerase-X family: controllers of DNA quality?
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- PMID: 15573140
- DOI: 10.1038/nrm1530
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Review
The DNA-polymerase-X family: controllers of DNA quality?
Nat Rev Mol Cell Biol.
2004 Dec.
Abstract
Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.
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