The maturation of correlations between cardiac and respiratory measures across sleep states in normal infants

Abstract

Coordination of cardiac and respiratory measures is not mature in newborn infants but develops during early life. The course of that development is assessed in this study. Twelve-hour recordings of electrocardiogram, electroencephalogram, digastric electromyogram, electrooculogram and expired CO2 were obtained from 25 normal infants at 1 week and 1, 2, 3, 4 and 6 months of age. Each 1-minute epoch was classified as quiet sleep, rapid eye movement (REM) sleep, waking or indeterminate state. In each sleep-waking state, the correlations of heart rate with respiratory rate, heart rate with respiratory rate variability and respiratory rate with its own variability were determined on a minute-by-minute basis for each recording. The relative extents of correlations between measures and the maturational trends of these correlations were profoundly influenced by sleep-waking state. During quiet sleep, two of the three correlations weakened significantly over the first month of life, but, in the waking state, the same correlations strengthened over this period. During quiet sleep and waking, the three correlations showed similar patterns of development, but the three showed dissimilar developmental trends during REM sleep. These dissimilarities may reflect changes in the nature of REM sleep consequent to myelination of rostral brain pathways.