[Action of vitamin D on mineralization]

Abstract

The effects of 1,25 (OH) (2)D on bone mineralization appear to be indirect by stimulating the calcium and phosphate supply, mainly by absorption from intestine. The disturbance in vitamin D action results in rickets in infancy and osteomalacia in adults. An association has been recently reported between mild vitamin D insufficiency and decreased bone mineral density in the elderly, which enhances the importance of appropriate vitamin D intake.