Review
[Vitamin D nuclear receptor and its signal transduction]
[Article in
Japanese]
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- PMID: 15577143
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Review
[Vitamin D nuclear receptor and its signal transduction]
[Article in
Japanese]
Clin Calcium.
2004 Oct.
Abstract
Vitamin D (VD) suppresses keratinocyte growth and induces its differentiation by binding to VD receptor. VD increases expression of phopholipase C and involucrin through VD response elements in the promoter. Vitamin D receptor (VDR) recruits mainly DRIP (vitamin D receptor interacting protein) during keratinocyte proliferation, but SRC (steroid receptor coactivator) during differentiation.
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