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. 2004 Dec;52(12):1492-4.
doi: 10.1248/cpb.52.1492.

New norditerpenoids with trypanocidal activity from Vitex trifolia

Fumiyuki Kiuchi  1 , Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda
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Free article

New norditerpenoids with trypanocidal activity from Vitex trifolia

Fumiyuki Kiuchi et al. Chem Pharm Bull (Tokyo). 2004 Dec.
Free article

Abstract

Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 microM (1), 36 microM (2), 34 microM (3), 34 microM (4), 66 microM (5), 66 microM (6), and >265 microM (7).

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