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Case Reports
. 2004 Nov 19;18(17):2325-7.
doi: 10.1097/00002030-200411190-00014.

Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment

Oliver Schildgen  1 , Carl Knud Schewe, Martin Vogel, Martin Däumer, Rolf Kaiser, Lutwin Weitner, Bertfried Matz, Jürgen Kurt Rockstroh
Affiliations
Case Reports

Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment

Oliver Schildgen et al. AIDS. .

Abstract

Three HIV-infected patients with chronic hepatitis B (genotype A) were switched to adefovir therapy after unsuccessful lamivudine treatment. Surprisingly, adefovir therapy failed, although none of the virus isolates displayed mutations known to be associated with adefovir resistance (A181V, N236T). In two isolates we identified hepatitis B virus DNA polymerase mutation L217R, in one case we found multiple frameshifts in the same region. In all cases adefovir was replaced by tenofovir, resulting in a significant drop in the viral load.

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