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. 2004 Dec 1;39(11):1709-12.
doi: 10.1086/425742. Epub 2004 Nov 9.

Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy

Guillaume Breton  1 , Xavier Duval, Candice Estellat, Xavier Poaletti, Daniel Bonnet, David Mvondo Mvondo, Pascale Longuet, Catherine Leport, Jean-Louis Vildé
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Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy

Guillaume Breton et al. Clin Infect Dis. .

Abstract

Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.

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