Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Dec;16(12):3181-95.
doi: 10.1105/tpc.104.161220.

The ubiquitin-proteasome pathway and plant development

Jennifer Moon  1 , Geraint Parry, Mark Estelle
Affiliations
Review

The ubiquitin-proteasome pathway and plant development

Jennifer Moon et al. Plant Cell. 2004 Dec.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Classes of E3 Ubiquitin Ligases in Plants. Cullin and cullin-like proteins are green, RING proteins are red, and substrate specificity factors are purple.
Figure 2.
Figure 2.
COP1 and the Light Response. (A) In the dark, the level of COP1 in the nucleus is high. After a light stimulus, the level decreases as COP1 moves into the cytoplasm. (B) COP1 interacts with many other proteins to facilitate protein degradation. The RING-finger protein CIP8 associates with the E2 enzyme Ubc8 as well as with COP1. COP10 has been shown to interact with both COP1 and the CSN. The four SPA proteins all interact with COP1. SPA1 may aid ubiquitination of targets when in the presence of lower concentrations of COP1. (C) Known light-regulated targets of COP1 include HY5, PHYA, and LAF. The degradation of each of these proteins appears to be dependent on the interaction of COP1 with different subsets of accessory proteins. Defined interactions are shown with arrows. See text for references.
Figure 3.
Figure 3.
Control of Signaling Pathways by Protein Degradation. (A) Light prevents degradation of HY5 by COP1, resulting in gene expression of certain AUX/IAA proteins. (B) Auxin promotes degradation of AUX/IAA proteins by SCFTIR1, thus releasing the inhibition of ARF-mediated gene expression. (C) Auxin and GA promote degradation of RGA by SCFSLY. (D) BTBETO controls ethylene production by facilitating degradation of ACS5. Ethylene prevents degradation of EIN3 by SCFEBF1/2, subsequently allowing gene expression. Rectangles denote E3 complexes, and circles denote their substrates.
See this image and copyright information in PMC

References

    1. Abel, S., Nguyen, M.D., and Theologis, A. (1995). The PS-IAA4/5-like family of early auxin-inducible mRNAs in Arabidopsis thaliana. J. Mol. Biol. 251, 533–549. - PubMed
    1. Achard, P., Vriezen, W.H., Van Der Straeten, D., and Harberd, N.P. (2003). Ethylene regulates arabidopsis development via the modulation of DELLA protein growth repressor function. Plant Cell 15, 2816–2825. - PMC - PubMed
    1. Andrade, M.A., Gonzalez-Guzman, M., Serrano, R., and Rodriguez, P.L. (2001). A combination of the F-box motif and kelch repeats defines a large Arabidopsis family of F-box proteins. Plant Mol. Biol. 46, 603–614. - PubMed
    1. Azevedo, C., Santos-Rosa, M.J., and Shirasu, K. (2001). The U-box protein family in plants. Trends Plant Sci. 6, 354–358. - PubMed
    1. Bates, P.W., and Vierstra, R.D. (1999). UPL1 and 2, two 405 kDa ubiquitin-protein ligases from Arabidopsis thaliana related to the HECT-domain protein family. Plant J. 20, 183–195. - PubMed

Publication types

MeSH terms

LinkOut - more resources