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Case Reports
. 2004 Dec;145(6):851-5.
doi: 10.1016/j.jpeds.2004.08.001.

Abnormal production of tumor necrosis factor (TNF) -- alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected]

Elisabetta Cortis  1 , Fabrizio De Benedetti, Antonella Insalaco, Stefania Cioschi, Flaminia Muratori, Leila E D'Urbano, Alberto G Ugazio
Affiliations
Case Reports

Abnormal production of tumor necrosis factor (TNF) -- alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected]

Elisabetta Cortis et al. J Pediatr. 2004 Dec.

Erratum in

  • J Pediatr. 2005 Feb;146(2):193

Abstract

We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-alpha by mononuclear cells of the proband and of the affected relatives was abnormally elevated.

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