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. 2005 Jan;76(1):184-7.
doi: 10.1086/427244.

The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis

Ann B Begovich, Stacy J Caillier, Heather C Alexander, Joanne M Penko, Stephen L Hauser, Lisa F Barcellos, Jorge R Oksenberg

The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis

Ann B Begovich et al. Am J Hum Genet. 2005 Jan.
No abstract available

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References

Electronic-Database Information

    1. dbSNP, http://www.ncbi.nlm.nih.gov/SNP/ (for PTPN22 R620W [accession number rs2476601])
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for RA, SLE, T1D, and MS)

References

    1. Baranzini S, Jeong MC, Butunoi C, Murray RS, Bernard CCA, Oksenberg JR (1999) B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 163:5133–5144 - PubMed
    1. Barcellos LF, Oksenberg JR, Begovich AB, Martin ER, Schmidt S, Vittinghoff E, Goodin DS, Pelletier D, Lincoln RR, Bucher P, Swerdlin A, Pericak-Vance MA, Haines JL, Hauser SL (2003) HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet 72:710–716 - PMC - PubMed
    1. Barcellos LF, Oksenberg JR, Green AJ, Bucher P, Rimmler JB, Schmidt S, Garcia ME, Lincoln RR, Pericak-Vance MA, Haines JL, Hauser SL (2002) Genetic basis for clinical expression in multiple sclerosis. Brain 125:150–15810.1093/brain/awf009 - DOI - PubMed
    1. Begovich AB, Carlton VEH, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, et al (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 75:330–337 - PMC - PubMed
    1. Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36:337–33810.1038/ng1323 - DOI - PubMed

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