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Review
. 2005 Jan 1;433(1):212-26.
doi: 10.1016/j.abb.2004.09.003.

Structure and functions of the GNAT superfamily of acetyltransferases

Matthew W Vetting  1 , Luiz Pedro S de Carvalho, Michael Yu, Subray S Hegde, Sophie Magnet, Steven L Roderick, John S Blanchard
Affiliations
Review

Structure and functions of the GNAT superfamily of acetyltransferases

Matthew W Vetting et al. Arch Biochem Biophys. .

Abstract

The Gcn5-related N-acetyltransferases are an enormous superfamily of enzymes that are universally distributed in nature and that use acyl-CoAs to acylate their cognate substrates. In this review, we will examine those members of this superfamily that have been both structurally and mechanistically characterized. These include aminoglycoside N-acetyltransferases, serotonin N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, the histone acetyltransferases, mycothiol synthase, protein N-myristoyltransferase, and the Fem family of amino acyl transferases.

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