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Review
. 2004 Dec;139(4):543-59.
doi: 10.1016/j.cbpc.2004.06.014.

Nutrient sensing and metabolic decisions

Janet E Lindsley  1 , Jared Rutter
Affiliations
Review

Nutrient sensing and metabolic decisions

Janet E Lindsley et al. Comp Biochem Physiol B Biochem Mol Biol. 2004 Dec.

Abstract

Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved from yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, mTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their similarities, differences and roles in disease.

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