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Comment
. 2004 Dec 14;101(50):17329-30.
doi: 10.1073/pnas.0408034101. Epub 2004 Dec 6.

Fragile X syndrome: (What's) lost in translation?

Kevin Miyashiro  1 , James Eberwine
Affiliations
Comment

Fragile X syndrome: (What's) lost in translation?

Kevin Miyashiro et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
A schematic of the Gp1 mGluR/FMRP pathway. Depicted is the Gp1 mGluR receptor coupled to the Gq-mediated signaling cascade. Gq signaling liberates DAG and IP3 through phospholipase C. G protein-coupled receptor kinase (GRK) 2/3 is known to antagonize this signaling pathway (20), and at least one GRK, GRK 4 mRNA, is a known FMRP cargo and is localized to dendrites (12). FMRP modulation of activity-dependent translation is downstream of PKC activation. The black box represents the unknown intermediates in this step. FMRP directly interacts with polyribosomes, and phosphorylation is thought to be one requirement in this step (3, 21). FMRP, in a messenger ribonucleoprotein complex containing FXR1P among other RNA-binding proteins, is known to bind a large number of mRNA cargoes where it may inhibit the translation of some or enhance the translation of others. One complicating factor at the synapse is that a number of receptor systems are known to modulate production of PKC, suggesting that multiple neuromodulatory receptors may be impacted by FMRP activity in a manner analogous to the Gp1 mGluR system.
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References

    1. Irwin, S. A., Patel, B., Idupulapati, M., Harris, J. B., Crisostomo, R. A., Larsen, B. P., Kooy, F., Willems, P. J., Cras, P., Kozlowski, P. B., et al. (2001) Am. J. Med. Genet. 98, 161–167. - PubMed
    1. Tiedge, H. & Brosius, J. (1992) J. Neurosci. 16, 7171–7181. - PMC - PubMed
    1. Ceman, S., O'Donnell, W. T., Reed, M., Patton, S., Pohl, J. & Warren, S. T. (2003) Hum. Mol. Genet. 12, 3295–3305. - PubMed
    1. Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J. & Greenough, W. T. (1997) Proc. Natl. Acad. Sci. USA 94, 5395–5400. - PMC - PubMed
    1. Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., Khaliq, H., de Vries, F. E., Lambers, F. A. E., Hatia, F., et al. (2004) Proc. Natl. Acad. Sci. USA 17504–17509. - PMC - PubMed