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. 2004 Sep;20(9):1026-31.
doi: 10.1089/aid.2004.20.1026.

Failure to detect human immunodeficiency virus type 1 superinfection in 28 HIV-seroconcordant individuals with high risk of reexposure to the virus

Bikram Chakraborty  1 , Luisa Valer, Carmen De Mendoza, Vicente Soriano, Miguel E Quiñones-Mateu
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Failure to detect human immunodeficiency virus type 1 superinfection in 28 HIV-seroconcordant individuals with high risk of reexposure to the virus

Bikram Chakraborty et al. AIDS Res Hum Retroviruses. 2004 Sep.

Abstract

We have examined the occurrence of HIV-1 superinfection in 14 HIV-seroconcordant couples (i.e., partners were independently infected with different HIV-1 strains) with high risk of reexposure to the virus. Phylogenetic analyses based on pol and env global sequences obtained from more than 100 longitudinal plasma samples (corresponding to a period of 1-4 years) failed to detect HIV-1 superinfection in this cohort of patients. Our results suggest that despite recent reports of HIV-1 reinfection, chronic HIV infection seems to confer protection against superinfection with a second HIV-1 strain.

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