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. 2004 Nov-Dec;30(6):582-93.
doi: 10.1023/b:rubi.0000049768.98894.f5.

[Peptide fragments and structural analogues of chemokine MPC-1: synthesis and effect on the MPC-1-induced migration of monocytes]

[Article in Russian]
M B Sidorova, A S Molokoedov, T I Aref'eva, N B Kukhtina, T L Krasnikova, Zh D Bespalova, V N Bushuev

[Peptide fragments and structural analogues of chemokine MPC-1: synthesis and effect on the MPC-1-induced migration of monocytes]

[Article in Russian]
M B Sidorova et al. Bioorg Khim. 2004 Nov-Dec.

Abstract

Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.

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