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. 2004 Dec 16;47(26):6439-42.
doi: 10.1021/jm049394l.

2,3-diaminopyridine bradykinin B1 receptor antagonists

Scott D Kuduk  1 , Christina Ng, Dong-Mei Feng, Jenny M-C Wai, Raymond S L Chang, Charles M Harrell, Kathy L Murphy, Richard W Ransom, Duane Reiss, Magnus Ivarsson, Glenn Mason, Susan Boyce, Cuyue Tang, Thomayant Prueksaritanont, Roger M Freidinger, Douglas J Pettibone, Mark G Bock
Affiliations

2,3-diaminopyridine bradykinin B1 receptor antagonists

Scott D Kuduk et al. J Med Chem. .

Abstract

Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. A series of 2,3-diaminopyridine B1 antagonists was optimized to have sub-nanomolar affinity and good pharmacokinetic properties. Lead compounds were shown to exhibit good efficacy in rabbit in vivo models of pain and inflammation.

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