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Review
. 2004 Dec;6(15):1361-7.
doi: 10.1016/j.micinf.2004.08.015.

Endotoxin recognition and signal transduction by the TLR4/MD2-complex

Katherine A Fitzgerald  1 , Daniel C Rowe, Douglas T Golenbock
Affiliations
Free article
Review

Endotoxin recognition and signal transduction by the TLR4/MD2-complex

Katherine A Fitzgerald et al. Microbes Infect. 2004 Dec.
Free article

Abstract

Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.

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