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Review
. 2005 Jan;54(1):4-6.
doi: 10.1136/gut.2004.047084.

Immune regulation and colitis: suppression of acute inflammation allows the development of chronic inflammatory bowel disease

B Eksteen  1 , L S K Walker, D H Adams
Affiliations
Review

Immune regulation and colitis: suppression of acute inflammation allows the development of chronic inflammatory bowel disease

B Eksteen et al. Gut. 2005 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Simplified pathways involved in the generation of effector and regulatory lymphocyte responses. Naïve lymphocytes that have been selected and matured in the thymus are able to enter secondary lymphoid tissue such as lymph nodes and Peyer’s patches where they interact with dendritic cells (DC) that have assimilated antigens in the gut. Interactions with DCs subsequently prime the naïve lymphocytes to the antigen and activate their differentiation into effector lymphocytes. Part of this differentiation is induction of tissue specific homing molecules that direct the effector cells back to the tissue where the antigen was found. During this process memory lymphocytes are also generated to allow for rapid expansion of effector cells if the specific antigen is encountered again. Regulation occurs at several levels with autoreactive lymphocytes being deleted in the thymus and generation of central/ thymic regulatory T cells (Tregs). Peripheral or induced Tregs are also generated locally by DC-lymphocyte interactions. Both sets of Tregs are able to control inflammation by the production of anti-inflammatory cytokines such as transforming growth factor β (TGF-β) and interleukin 10 (IL-10).
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