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Multicenter Study
. 2004 Dec 14;63(11):2146-8.
doi: 10.1212/01.wnl.0000145661.01675.a8.

Markedly elevated GAD antibodies in SPS: effects of age and illness duration

B B Murinson  1 , M Butler, K Marfurt, S Gleason, P De Camilli, M Solimena
Affiliations
Multicenter Study

Markedly elevated GAD antibodies in SPS: effects of age and illness duration

B B Murinson et al. Neurology. .

Abstract

Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.

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Comment in

  • GAD antibodies in stiff-person syndrome.
    Chang T, Lang B. Chang T, et al. Neurology. 2004 Dec 14;63(11):1999-2000. doi: 10.1212/01.wnl.0000147536.50606.61. Neurology. 2004. PMID: 15596739 No abstract available.

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