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Review
. 2004 Oct;53(10):509-16.
doi: 10.1007/s00011-004-1286-9.

Histamine H3-receptor isoforms

R A Bakker  1
Affiliations
Review

Histamine H3-receptor isoforms

R A Bakker. Inflamm Res. 2004 Oct.

Abstract

Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.

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