Review
doi: 10.1016/j.jinorgbio.2004.09.025.
Root effect hemoglobins
Affiliations
- PMID: 15598496
- DOI: 10.1016/j.jinorgbio.2004.09.025
Item in Clipboard
Review
Root effect hemoglobins
J Inorg Biochem.
2005 Jan.
Abstract
The Root effect describes an extreme pH sensitivity expressed in the hemoglobins of certain fish, in which it plays a unique physiological role. This review describes our general understanding of the effect of protons on the oxygen binding properties of hemoglobin and the particular properties which characterize Root effect proteins. The development of our understanding of the molecular origins of this effect is outlined and the role played by our ever expanding knowledge of protein structure is highlighted. The present state of our knowledge is detailed.
Similar articles
-
High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: the role of histidine residues in modulating the strength of the root effect.Proteins. 2006 Nov 1;65(2):490-8. doi: 10.1002/prot.21114. Proteins. 2006. PMID: 16909420
-
Movements at the hemoglobin A-hemes and their role in ligand binding, analyzed by X-ray crystallography.Biopolymers. 2009 Dec;91(12):1056-63. doi: 10.1002/bip.21197. Biopolymers. 2009. PMID: 19353640
-
Molecular modelling of Trematomus newnesi Hb 1: insights for a lowered oxygen affinity and lack of root effect.Proteins. 2000 May 1;39(2):155-65. Proteins. 2000. PMID: 10737936
-
Protein fold and structure in the truncated (2/2) globin family.Gene. 2007 Aug 15;398(1-2):2-11. doi: 10.1016/j.gene.2007.02.045. Epub 2007 Apr 29. Gene. 2007. PMID: 17532150 Review.
-
Is cooperative oxygen binding by hemoglobin really understood?Nat Struct Biol. 1999 Apr;6(4):351-8. doi: 10.1038/7586. Nat Struct Biol. 1999. PMID: 10201404 Review.
Cited by
-
Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport.Physiology (Bethesda). 2016 May;31(3):223-32. doi: 10.1152/physiol.00060.2015. Physiology (Bethesda). 2016. PMID: 27053736 Free PMC article. Review.
-
Striped mullet (Mugil cephalus) hemoglobin system: multiplicity and functional properties.J Comp Physiol B. 2011 Feb;181(2):187-97. doi: 10.1007/s00360-010-0525-3. Epub 2010 Nov 3. J Comp Physiol B. 2011. PMID: 21046405
-
A novel perspective on the evolutionary loss of plasma-accessible carbonic anhydrase at the teleost gill.J Exp Biol. 2023 Oct 1;226(19):jeb246016. doi: 10.1242/jeb.246016. Epub 2023 Oct 11. J Exp Biol. 2023. PMID: 37694374 Free PMC article.
-
Quaternary Structure Transitions of Human Hemoglobin: An Atomic-Level View of the Functional Intermediate States.J Chem Inf Model. 2021 Aug 23;61(8):3988-3999. doi: 10.1021/acs.jcim.1c00315. Epub 2021 Aug 10. J Chem Inf Model. 2021. PMID: 34375114 Free PMC article.
-
Evolution of Hemoglobin Genes in Codfishes Influenced by Ocean Depth.Sci Rep. 2017 Aug 11;7(1):7956. doi: 10.1038/s41598-017-08286-2. Sci Rep. 2017. PMID: 28801564 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
